Harnessing naturally randomized transcription to infer regulatory relationships among genes

Abstract

We develop an approach utilizing randomized genotypes to rigorously infer causal regulatory relationships among genes at the transcriptional level, based on experiments in which genotyping and expression profiling are performed. This approach can be used to build transcriptional regulatory networks and to identify putative regulators of genes. We apply the method to an experiment in yeast, in which genes known to be in the same processes and functions are recovered in the resulting transcriptional regulatory network.

Publication
Genome Biology, 8 (10): R219
DOI
10.1186/gb-2007-8-10-r219
Date
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